Table 6.
MiRs involved in chemoradiosensitivity or chemoradioresistance in CRC and mCRC.
| Anti-OncomiRs That Enhance Chemoradiosensitivity | |||||
|---|---|---|---|---|---|
| Family | MiRs | Verified Targets in CRC or Other Cancers | Sample Source | Target for miRNA | Ref. |
| miR-148 | miR-148a/b, miR-152 |
MiR-148a enhances the chemoradiosensitivity of patients with rectal cancer. | Tumor tissue | c-Met | [113] |
| miR-34 | miR-34a/b/c/d | MiR-34a attenuates the chemoresistance of colon cancer to 5-FU by inhibiting E2F3 and SIRT1. The miR-34a mimic MRX34 is the first synthetic miRNA to undergo clinical trials. | Serum | E2F3; SIRT1 | [87,143] |