Table 2.
Records included in the review based on the search performed regarding undenatured type II collagen for managing clinical signs of osteoarthritis and joint support in dogs.
| Records of UC-II | Year of Publication | Study Design | Blind | Ref. | |
|---|---|---|---|---|---|
| 1 | Efficacy and safety of glycosylated undenatured type-II collagen (UC-II) in therapy of arthritic dogs | 2005 | Type I | Yes | [55] |
| 2 | Therapeutic Efficacy and Safety of Undenatured Type II Collagen Singly or in Combination with Glucosamine and Chondroitin in Arthritic Dogs | 2007 | Type I | Double-blind | [30] |
| 3 | Therapeutic efficacy and safety of undenatured type-II collagen (UC-II) alone or in combination with (-)-hydroxycitric acid and chromemate in arthritic dogs | 2007 | Type I | No information | [56] |
| 4 | Suppression of arthritic pain in dogs by undenatured type-II collagen (UC-II) treatment quantitatively assessed by ground force plate | 2009 | Abstract congress Type I |
No information | [57] |
| 5 | Comparative therapeutic efficacy and safety of type-II collagen (UC-II), glucosamine and chondroitin in arthritic dogs: pain evaluation by ground force plate | 2012 | Type I | Double-blind | [58] |
| 6 | An Overview of a Novel, Water-Soluble Undenatured Type II Collagen (NEXT-II) | 2015 | Type I | Yes | [59] |
| 7 | Evaluation of the Effects of Undenatured Type II Collagen (UC-II) as Compared to Robenacoxib on the Mobility Impairment Induced by Osteoarthritis in Dogs | 2019 | Type I | Yes | [60] |
| 8 | Chondroprotective efficacy of undenatured collagen type II on canine osteoarthritis secondary to medial patellar luxation | 2020 | Type II | No | [61] |
| 9 | Undenatured type II collagen mitigates inflammation and cartilage degeneration in healthy untrained Labrador retrievers after exercise | 2020 | Abstract congress Type I |
No information | [62] |
| 10 | Undenatured type II collagen mitigates inflammation and cartilage degeneration in healthy Labrador Retrievers during an exercise regimen | 2021 | Type I | No information | [63] |
| 11 | Long-term supplementation with an undenatured type-II collagen (UC-II) formulation in dogs with degenerative joint disease: Exploratory study | 2022 | Type III | No | [64] |
| 12 | Evaluation of clinical efficacy of undenatured type II collagen supplementation compared to cimicoxib and their association in dogs affected by natural occurring osteoarthritis | 2022 | Type I | Yes | [65] |
| 13 | Impact of supplemented undenatured type II collagen on pain and mobility in healthy Labrador Retrievers during an exercise regimen | 2022 | Type I | No information | [66] |
| 14 | 1H-NMR metabolomic profile of healthy and osteoarthritic canine synovial fluid before and after UC-II supplementation | 2022 | Type II | No | [67] |