Table 7.

Literature overview of evidence regarding the combination of Undenatured Type II Collagen and Boswellia serrata for the management of osteoarthritis (OA) and joint support in dogs.

Reference	Study Design and Duration	Objective	Main Results
Martello et al. 2018 [36]	Thirteen client-owned dogs with OA -Undenatured Type II Collagen + Boswellia serrata + GLU + CHO (Group I) 60 days	Conduct a general examination and orthopaedic examination and evaluate degree of lameness, overall classification (failure, improved, success) and Helsinki Chronic Pain Index (HCPI)	In 84% of patients, the clinical status was “improved”, in 8% it was “successful” and in 8% it “failed”. In 69% of patients, the degree of lameness improved Dogs with an HCPI between 11 and 19 had a final score similar to their initial score The three cases with the highest index (HCPI > 20) showed a final score that was reduced significantly after 60 days of treatment
Martello et al. 2022 [37]	Forty client-owned dogs with OA -Placebo (Group I) -Undenatured Type II Collagen + Boswellia serrata + GLU + CHO (Group II) 60 days	Evaluation of clinical signs of OA by the veterinarian and chronic pain questionnaires using HCPI by the owner	An improvement in signs of OA was recorded in Group II (p < 0.05) Lower scores for HCPI were found in Group II (p < 0.05)

Abbreviations: Glucosamine (GLU), Chondroitin (CHO).