Table 2.
Significantly differentially expressed proteins between ALA‐A2 treated versus untreated A549 lung adenocarcinoma cells
| SwisProt ID | Gene name | Protein name | %Coverage | Number of matched peptides |
MW [kDa] |
pI |
Fold‐change [treated/ untreated] |
p‐value |
|---|---|---|---|---|---|---|---|---|
| Proteins whose expression was upregulated in ALA‐A2 treated cells | ||||||||
| Q13148 | TADBP | TAR DNA‐binding protein 43 | 2.90 | 1 | 44.74 | 5.85 | 4.07 | 0.0348 |
| Q9UKM9 | RALY |
RNA‐binding protein Raly (Autoantigen p542) |
6.86 | 1 | 32.463 | 9.20 | 3.57 | 0.0209 |
| P20073 | ANXA7 | Annexin A7 | 8.61 | 1 | 52.739 | 5.52 | 3.29 | 0.0011 |
| O00299 | CLIC1 | Chloride intracellular channel protein 1 | 11.20 | 2 | 26.923 | 5.09 | 3.02 | 0.0212 |
| P09525 | ANXA4 | Annexin A4 | 18.81 | 1 | 35.883 | 5.84 | 2.98 | 0.0074 |
| Q02878 | RL6 | 60S ribosomal protein L6 | 19.10 | 2 | 32.728 | 10.59 | 2.87 | 0.0319 |
| P26639 | SYTC | Threonine‐tRNA ligase 1 | 4.70 | 1 | 83.435 | 6.23 | 2.61 | 0.0100 |
| P50991 | TCPD | T‐complex protein 1 subunit delta | 13.36 | 3 | 57.924 | 8.13 | 2.39 | 0.0255 |
| Q99729 | ROAA | Heterogeneous nuclear ribonucleoprotein A/B | 5.42 | 1 | 36.225 | 8.21 | 2.35 | 0.0248 |
| O00410 | IPO5 | Importin‐5 | 6.38 | 3 | 123.63 | 4.83 | 2.22 | 0.0010 |
| P42704 | LPPRC | Leucine‐rich PPR motif‐containing protein | 14.92 | 11 | 157.905 | 5.53 | 2.06 | 0.0091 |
| P14923 | PLAK | Junction plakoglobin | 7.52 | 2 | 81.745 | 5.75 | 2.05 | 0.0041 |
| Proteins whose expression was downregulated in ALA‐A2 treated cells | ||||||||
| Q6FI13 | H2A2A | Histone H2A type 2‐A | 62.31 | 19 | 14.095 | 10.90 | 0.48 | 0.0438 |
| Q9NZL4 | HPBP1 | Hsp70‐binding protein 1 | 8.36 | 2 | 39.303 | 5.13 | 0.48 | 0.0067 |
| P49368 | TCPG | T‐complex protein 1 subunit gamma | 10.83 | 3 | 60.534 | 6.10 | 0.46 | 0.0336 |
| P14618 | KPYM | Pyruvate kinase PKM | 54.43 | 32 | 57.937 | 7.95 | 0.43 | 0.0258 |
| P37837 | TALDO | Transaldolase | 17.80 | 3 | 37.54 | 6.36 | 0.43 | 0.0089 |
| P62987 | UBA52 | Ubiquitin‐60S ribosomal protein L40 | 52.34 | 4 | 14.728 | 6.56 | 0.41 | 0.0272 |
| P08238 | HSP90AB1 | Heat shock protein HSP90 beta | 37.15 | 25 | 83.264 | 4.96 | 0.40 | 0.0039 |
| P14625 | ENPL | Endoplasmin | 17.68 | 10 | 92.469 | 4.73 | 0.38 | 0.0301 |
| P29401 | TKT | Transketolase | 39.33 | 20 | 67.878 | 7.58 | 0.35 | 0.0004 |
| P05783 | K1C18 | Keratin, type I cytoskeletal 18 | 53.02 | 42 | 48.058 | 5.34 | 0.35 | 0.0149 |
| P08727 | K1C19 | Keratin, type I cytoskeletal 19 | 23.75 | 7 | 44.106 | 5.05 | 0.34 | 0.0327 |
| P84103 | SRSF3 | Serine/arginine‐rich splicing factor 3 | 12.80 | 1 | 19.33 | 11.64 | 0.33 | 0.0102 |
| P16402 | H13 | Histone H1.3 | 25.34 | 2 | 22.35 | 11.02 | 0.32 | 0.0227 |
| P04406 | G3P | Glyceraldehyde‐3‐phosphate dehydrogenase | 60.00 | 32 | 36.053 | 8.58 | 0.32 | 0.0088 |
| P26641 | EF1G | Elongation factor 1‐gamma | 20.14 | 4 | 50.119 | 6.27 | 0.31 | 0.0123 |
| O60218 | AK1BA | Aldo‐keto reductase family 1 member B10 | 71.52 | 26 | 36.02 | 7.66 | 0.29 | 0.0120 |
| P07437 | TBB5 | Tubulin beta chain | 53.15 | 39 | 49.671 | 4.78 | 0.27 | 0.0041 |
| P62805 | H4 | Histone H4 | 57.28 | 15 | 11.367 | 11.36 | 0.26 | 0.0302 |
| Q06830 | PRDX1 | Peroxiredoxin‐1 | 29.65 | 10 | 22.11 | 8.27 | 0.26 | 0.0190 |
| P07900 | HSP90AA1 | Heat shock protein HSP90 alpha | 37.02 | 24 | 84.66 | 4.94 | 0.26 | 0.0069 |
| P22626 | ROA2 | Heterogeneous nuclear ribonucleoproteins A2/B1 | 24.93 | 3 | 37.43 | 8.97 | 0.25 | 0.0281 |
| P11142 | HSPA8 | Heat shock 70 kDa protein 8 | 28.79 | 21 | 70.898 | 5.37 | 0.25 | 0.0056 |
| P08865 | RSSA | 40S ribosomal protein SA | 17.97 | 3 | 32.854 | 4.79 | 0.25 | 0.0285 |
| Q5VTE0 | EF1A3 | Elongation factor 1‐alpha‐like 3 | 35.93 | 19 | 50.185 | 9.15 | 0.15 | 0.0061 |
| P63261 | ACTG | Actin, cytoplasmic 2 | 63.20 | 53 | 41.793 | 5.31 | 0.09 | 0.0030 |
| P21359 | NF1 | Neurofibromin | 1.02 | 1 | 319.372 | 7.12 | 0.07 | 0.0030 |