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. 2023 Feb 24;17:1114037. doi: 10.3389/fncel.2023.1114037

FIGURE 2.

FIGURE 2

GABA transmission reduction play an important role in E-I rebalance in CA1. (A,B) Whole-cell patch clamp recordings from CA1 pyramidal neurons in the slices from the Kir2.1 (–) and the Kir2.1 (+) mice. Representatives and bar graph of the spontaneous excitatory and inhibitory postsynaptic currents (sEPSCs and sIPSCs). Data are mean ± SEM (n = 12 recordings/6 mice per group, ANOVA*p < 0.01). (C,D) Whole-cell patch clamp recordings from CA1 pyramidal neurons in the slices from the Kir2.1 (–) and the Kir2.1 (+) mice. Representatives and bar graph of the miniature excitatory and inhibitory postsynaptic currents (mEPSCs and mIPSCs). Data are mean ± SEM (n = 12 recordings/6 mice per group, ANOVA*p < 0.01). (E) The stimulus intensities are plotted against the evoked EPSC and IPSC recorded in the CA1 area of the hippocampus from the Kir2.1 (–) and the Kir2.1 (+) mice. Data are mean ± SEM (n = 10 recordings/5 mice per group), and the excitatory divide inhibitory ratio remained comparable between each groups.