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. 2023 Feb 24;17:1114037. doi: 10.3389/fncel.2023.1114037

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Copyright © 2023 Tian, Cai, Qin, Wang, Wang and Yang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Homeostatic modulation of forebrain E-I balance via GABA transmission related to cognitive level and experience. (A) The Kir2.1 (+) mice show abnormal performance in a hidden platform version of the Morris water maze. The latency to reach a hidden platform is plotted against the blocks of trials. N = 8 mice per group, t-test, *p < 0.05 and **p < 0.01. (B) The percentage of time spent in search of a hidden platform in the target quadrant during the probe trial, t-test, *p < 0.01. (C,D) Whole-cell patch clamp recordings from CA1 pyramidal neurons in the slices from the Kir2.1 (–) and the Kir2.1 (+) mice. Representatives and bar graph of the miniature excitatory and inhibitory postsynaptic currents (mEPSCs and mIPSCs). Data are mean ± SEM, (n = 10 recordings/4 mice per group, ANOVA, *p < 0.05 and **p < 0.01).