Table 3:
Comparison of 3-year cumulative incidence of all-cause and cause-specific mortality from the ISCHEMIA-CKD (eGFR <30 mL/min/1.73 m2) and ISCHEMIA (eGFR ≥30 mL/min/1.73 m2) trials
| Cumulative Incidence Function | ISCHEMIA-CKD (at 3 Year) (eGFR <30 mL/min/1.73 m2 or on dialysis) |
ISCHEMIA (at 3 Year) (eGFR ≥ 30 mL/min/1.73 m2) |
||
|---|---|---|---|---|
| Randomized Strategy | Invasive (N = 388) | Conservative (N = 389) | Invasive (N= 2,588) | Conservative (N = 2,591) |
| All-cause death, n (%) | 94 (27.2) | 98 (27.8) | 145 (4.3) | 144 (4.3) |
| Cause-specific death, n (%) | ||||
| Cardiovascular cause of death | 49 (14.6) | 45 (12.6) | 64 (2.1) | 69 (2.2) |
| Sudden cardiac death | 22 (6.5) | 22 (6.0) | 28 (0.8) | 38 (1.3) |
| Heart failure/shock | 6 (1.7) | 6 (1.5) | 9 (0.3) | 4 (0.1) |
| Acute myocardial infarction | 5 (1.6) | 10 (3.2) | 9 (0.4) | 16 (0.4) |
| Cardiovascular procedure | 6 (1.6) | 2 (0.6) | 6 (0.2) | 6 (0.2) |
| Other cardiovascular | 10 (3.3) | 5 (1.5) | 12 (0.4) | 5 (0.2) |
| Non-cardiovascular cause of death | 31 (8.4) | 28 (8.2) | 69 (1.8) | 49 (1.3) |
| Malignancy | 10 (2.8) | 4 (1.3) | 41 (1.0) | 20 (0.4) |
| Infection (includes sepsis) | 16 (4.7) | 16 (4.8) | 11 (0.2) | 15 (0.5) |
| Renal | 1 (0.3) | 6 (1.7) | NA | NA |
| Other*,2 | 4 (0.5)1 | 2 (0.5)1 | 17 (0.6)2 | 14 (0.4)2 |
| Undetermined cause of death | 14 (4.2) | 25 (6.9) | 12 (0.4) | 26 (0.7) |
eGFR = estimate glomerular filtration rate
*
Other in ISCHEMIA-CKD includes hemorrhage not intracranial, non-cardiovascular surgery, pulmonary.
†
Other in ISCHEMIA includes renal plus GI, pulmonary, suicide, trauma, drug overdose, hemorrhage, hepatic, stroke, ischemic bowel, pulmonary embolism and SAH.