Figure 2.

Proteomics analysis of abdominal sub-cutaneous adipose tissues from control subjects and patients affected by AL amyloidosis. (A) Comparison among the average number of proteins identified in control subjects (C, n = 14) and patients affected by AL amyloidosis (AL$\kappa$, n = 15; AL$\mathrm{\lambda }$, n = 15); ANOVA and Tukey’s test (* p ≤ 0.05). (B) Principal component analysis (PCA) by processing proteins differentially abundant (DAPs) in C, AL$\kappa$ and AL$\mathrm{\lambda }$ groups. (C) Hierarchical clustering and heat map showing the high-confidence DAPs in C, AL$\kappa$ and AL$\mathrm{\lambda }$ protein profiles (LDA, p ≤ 0.01). (D) Spearman’s correlation using DAPs and the corresponding average SpC values in C and AL$\kappa$, (E) C and AL$\mathrm{\lambda }$, and (F) AL$\kappa$ and AL$\mathrm{\lambda }$ groups.