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. 2023 Mar 1;13(5):924. doi: 10.3390/diagnostics13050924

Table 2.

Intergroup Rhabdomyosarcoma Study Group Clinical Classification System for Rhabdomyosarcoma.

Clinical Group Extent of Disease, Resectability, and Margin Status
I A: localized tumor, confined to site of origin, completely resected.
B: localized tumor, infiltrating beyond site of origin, completely resected.
II A: localized tumor, gross total resection, but with microscopic residual disease.
B: locally extensive tumor (spread to regional lymph nodes), completely resected.
III A: localized or locally extensive tumor, gross residual disease after biopsy only.
B: localized or locally extensive tumor, gross residual disease after major resection (≥50% debulking).
IV Any size primary tumor, with or without regional lymph node involvement, with distant metastases, irrespective of surgical approach to primary tumor.