SRE Skeletal-related event
OS	overall survival
NTX	N-telopeptide of type I collagen
EMT	epithelial-to-mesenchymal transition
ADT	androgen deprivation therapy
AME	The Italian Association of Clinical Endocrinologists
AR	Androgen receptor
AR-Vs	androgen receptor variants
BALP	bone alkaline phosphatase
BMD	bone mineral density
BMI	body mass index
BMP7	bone morphogenetic protein
CAF	Cancer-associated fibroblast
c-Myc	Cellular-myelocytomatosis viral oncogene
CRPC	castration resistant PC
CTC	circulating tumor cell
CTIBL	cancer treatment-induced bone loss
DC	dentritic cell
DKK	Dickkopf
DXA	dual-energy x-ray absorptiometry
EAA	The European Academy of Andrology
ECM	extracellular matrix
EMT	epithelial-to-mesenchymal transition
GAS	growth arrest-specific
GWAS	genome-wide expression
IBSP	integrin-binding sialoprotein
IGF-IR	IGF type I receptor
iMCs	immature myeloid cells
INFγ	interferon γ
LHRH	Hormone-releasing hormone
LOX	Lysyl oxidase
LPA	lysophosphatidic acid
Lu	Lutetium
mCRPC	metastatic CRPC
MDSC	Myeloid-derived suppressor cells
MPP	Matrix metalloproteinase
NTX	N-telopeptide of type I collagen
ONJ	osteonecrosis of the jaw
OPG	Osteoprotegerin
ORR	Overall response rate
OS	overall survival
PC Prostate cancer
PSA	Prostate-Specific Antigen
PSMA	prostate-specific membrane antigen
PTHrP	parathyroid hormone-related protein
QoL	quality of life
RLT	radioligant therapy
RR	relative risk
RT	radiotherapy
SCC	spinal cord compression
SERM	selective estrogen receptor modulators
SRE Skeletal-related event
TAM	Tumor-associated macrophage
TAN	neutrophil
TGF-β2	transforming growth factor beta
VEGFR-1	vascular endothelial growth factor receptor-1