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. 2023 Feb 23;15(5):1427. doi: 10.3390/cancers15051427

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© 2023 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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scRNA-seq identifies the changes in tumor-infiltrating immune cells. (A). UMAP plot showing CD45⁺ immune cells colored by computationally determined clusters based on scRNA-seq data in the Panc02 tumor-bearing mouse model (above). The frequencies of cell composition in the tumor-infiltrating CD45⁺ immune cells with the control group (not subjected to ablation, n = 14,837) and ablation group (n = 11,247) (below). (B). Dotplot showing the top 10 marker genes across five different CD45⁺ immune cell subgroups. (C). Percentages of cells in the control group and ablation group among the different cell subgroups of CD45⁺ immune cells.