Table 10.
Clinical characteristics of HR HPV DNA and E6/E7 mRNA HPV tests.
| Test | Cytology | Sensitivity | CI | Specificity | CI | PPV | CI | NPV | CI |
|---|---|---|---|---|---|---|---|---|---|
| (%) | (95%) | (%) | (95%) | (%) | (95%) | (%) | (95%) | ||
| HPV DNA | ASCUS | 67.6 *** | 55.2–78.5 | 75.6 | 66.9–83.0 | 61.3 | 49.4–72.4 | 80.4 * | 71.8–87.3 |
| LSIL | 88.0 ** | 75.7–95.5 | 75.6 | 66.9–83.0 | 60.3 | 48.1–71.6 | 93.8 * | 86.9–97.7 | |
| HSIL | 98.2 | 90.1–100 | 75.6 | 66.9–83.0 | 64.6 | 53.3–74.9 | 98.9 | 94.0–100 | |
| E6/E7 mRNA HPV | ASCUS | 29.4 | 19.0–41.7 | 89.1 ** | 82.0–94.0 | 60.6 | 42.1–77.1 | 68.8 | 60.9–76.0 |
| LSIL | 60.0 | 45.2–73.6 | 89.1 ** | 82.0–94.0 | 69.8 *** | 53.9–82.8 | 84.1 | 76.6–90.0 | |
| HSIL | 88.9 | 77.4–95.8 | 89.1 ** | 82.0–94.0 | 78.7 *** | 66.3–88.1 | 94.6 | 88.7–98.0 |
* p < 0.05; ** p < 0.005; *** p < 0.001. CI (95%)—95% confidence interval; PPV—positive predictive value; NPV—negative predictive value; NILM—negative for intraepithelial lesion or malignancy; ASCUS—atypical squamous cells of unknown significance; LSIL—low-grade squamous intraepithelial lesions; HSIL—high-grade squamous intraepithelial lesions.