A 67 year old female patient with jaundice and abdominal pain. Endoscopic ultrasound biopsy confirmed poorly differentiated PDAC and a biliary stent was placed (asterisk). MDCT shows expansive pancreatic formation located in the cephalic portion, with poorly defined limits, measuring approximately 54 × 32 mm (A). Exophytic tumor (T), encompassing the SMA and distal branches (white arrow) and the spleno–mesenteric–portal confluence, extending towards the superior mesenteric vein (encasement) (B,C). Cephalically it extends towards the celiac trunk, encompassing its terminal branches (black arrow) (D).