Table 2.
Immunoregulatory effects of putative IM and CpG-containing ODN a in GM-080 and BCRC 16100.
| Code | Core Sequence | Strain | Sequence | IFN-r (pg/mL) b | IL-12 (pg/mL) c |
|---|---|---|---|---|---|
| IM3 | TCAAGCTTGA | TCAAGCTTGA | ND d | ND | |
| IM4 | TCAAGCTTGA | GM-080 | CAAGCGTCAAGCTTGAATGA | ND | ND |
| IM5 | GM-080 | AAAAATTCAAGCTTGATAGT | ND | 609.8 ± 227.69 | |
| IM6 | GM-080 | CCATCGTCAAGCTTGACTTG | ND | ND | |
| IM7 | GM-080 | CCCTAATCAAGCTTGATTAA | ND | ND | |
| IM8 | BCRC 16100 | GCAGCTTCAAGCTTGAAAAA | ND | ND | |
| IM9 | BCRC 16100 | CCGGCCTCAAGCTTGAATTG | ND | ND | |
| IM10 | BCRC 16100 | TTTCATTCAAGCTTGACGCT | ND | ND | |
| IM11 | BCRC 16100 | CCTTAATCAAGCTTGATTAG | ND | ND | |
| ODN1 | GACGATCGTC | GM-080 | GCTTGACGATCGTCTCTGGA | ND | 38.8 ± 65.2 |
| ODN2 | ACGACGTCGT | GM-080 | GGTCACGACGTCGTTTACAAA | 490 ± 272.74 | 46.1 ± 32.88 |
| ODN3 | GACGATCGTC | BCRC 16100 | AATTGACGATCGTCTAATTC | ND | ND |
| ODN4 | BCRC 16100 | TGTCGACGATCGTCGTCTGT | ND | ND | |
| ODN5 | BCRC 16100 | CAGAGACGATCGTCAAGCGA | 77.381 ± 5.4 | ND | |
| ODN6 | ACGACGTCGT | BCRC 16100 | CGTCACGACGTCGTGACCGGC | ND | ND |
a ODN, oligonucleotides. b Treatment concentration was 0.125 µM. Data are presented as means ± standard deviations. c Treatment concentration was 1 µM. Data are presented as means ± standard deviations. d ND, not detected.