Figure 1.

The phases of acute wound healing, including hemostasis (I), inflammation (II), proliferation (III), and remodeling (IV). Hemostasis begins soon after wounding with vasoconstriction and blood clot formation. This is followed by the infiltration of inflammatory cells. Then, re-epithelialization occurs with collagen deposition and angiogenesis during the proliferation phase. Finally, the remodeling phase occurs with collagen remodeling and maturation, wound contraction, and scar tissue formation.