Figure 3.

The events and molecules associated with hypertrophic scar (HTS) formation. The pro-fibrotic molecules generated from the high-density blood clot induce excessive inflammation, angiogenesis, and prolonged re-epithelization. The resultant excessive production of extracellular matrix and fibroblast differentiation and improper matrix remodeling then causes formation of hypertrophic scarring. Molecules with increased expression are denoted with (+), whereas those with decreased expression are denoted with (−). The players included in this figure are discussed in the text.