Figure 6.

Relative expression of circulating miRNA-125b-5p, miRNA-29a, miRNA-29c, and miRNA-191-5p in serum of APP_swe/PS1_dE9 transgenic animal model of AD. (A) Serum samples from transgenic mice at 15 months of age were extracted and processed for miRNA detection by qRT-PCR. Data are represented as mean ± SEM of 5 sera samples performed in triplicate. (B) Table illustrating the statistically significant differences in terms of relative expression of miRNAs between the FAβ_1–42-infused animal model (day 21) and the APPswe/PS1dE9 transgenic animal model of AD. Statistical comparisons between the transgenic and control group were performed using the Mann–Whitney test. * p ≤ 0.05, ** p ≤ 0.01, *** p ≤ 0.001.