Table 3.
Sensitivity and specificity of Neurofilament in CSF. Reference values for neurofilaments in the cerebrospinal fluid. Demonstrated are sensitivity, specificity and positive and negative predictive values for different neurofilament cut-off values for distinguishing ALS patients from either ALS mimics, disease controls or healthy controls.
| Neurofilament | Cut-Off [pg/mL] | Sensitivity (95% CI) [%] | Specificity (95% CI) [%] | NPV (95% CI) [%] | PPV (95% CI) [%] | ALS vs. | Study |
|---|---|---|---|---|---|---|---|
| NfL | >2200 | 77 (71–82) | 88 (79–94) | 56 (48–65) | 95 (91–98) | ALS mimics | [105] |
| >2200 | - | 85 (79–90) | 75 (69–80) | 87 (81–91) | Other controls | [105] | |
| pNfH | >560 | 83 (78–88) | 80 (70–88) | 62 (52–71) | 93 (88–95) | ALS mimics | [105] |
| >560 | - | 77 (71–83) | 79 (72–84) | 82 (77–86) | Other controls | [105] | |
| NfL | >3819 | 88.4 (78.8–94) | 84.7 (76.8–90.2) | - | - | Disease controls | [100] |
| >2453 | 85.4 | 78 | - | - | ALS mimics | [100] | |
| pNfH | >618 | 94.2 (86–97.7) | 74.8 (66–81.9) | - | - | Disease controls | [100] |
| >768 | 90.7 | 88 | 76 | - | ALS mimics | [100] | |
| NfL | 1431 | 79 (66.1–87.6) | 86.4 (75.7–93.6 | - | - | Controls | [103] |
| pNFH | 568.5 | 78.7 (67.7–87.3) | 93.3 (85.1–97.8) | - | - | Controls | [103] |