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. 2023 Feb 27;12(5):761. doi: 10.3390/cells12050761

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© 2023 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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RNA sequencing analysis of first molars isolated from E18.5 WT and K14Cre;Jagged1^fl/fl mouse embryos. (A) Experimental approach. Molars were isolated from E18.5 K14Cre;Jagged1^fl/fl embryos and WT littermates. Their transcriptome was isolated via mRNA sequencing. (B) Volcano plot showing downregulated (red arrow) and upregulated (green arrow) genes in K14Cre;Jagged1^fl/fl mutant mice compared to the WT littermates. (C) Pie chart representation of unbiased Gene Ontology Analysis—Molecular Function. (D) Hypergeometric representation of unbiased GO—Biological Processes analysis showing the upregulated (Da) and downregulated (Db) genes in the K14Cre;Jagged1^fl/fl molars. (E) STRING analysis of selected protein networks whose gene expression was found to be significantly affected by Jagged1 deletion in the dental epithelium. (F) Heatmaps showing the main deregulated genes involved in odontogenesis and in the Wnt signaling pathway in K14Cre;Jagged1^fl/fl molars.