Table 1.
Demographic, clinical, and biological characteristics of patients with infectious mononucleosis, stratified by baseline blood platelet count during hospital admission.
| Blood platelet count | |||||||
|---|---|---|---|---|---|---|---|
| >150 ×109/L | 100–150 ×109/L | <100 ×109/L | P-value | ||||
| No. | No. | No. | |||||
| Age (years) | 281 | 19 (17–23) | 87 | 18 (17–23) | 32 | 18 (17–29) | 0.943 |
| Sex (male) | 281 | 144 (51.2) | 87 | 49 (56.3) | 32 | 15 (46.9) | 0.939 |
| Sore throat | 279 | 221 (79.2) | 87 | 54 (62.1) | 32 | 13 (40.6) | <0.001 |
| Lymphadenopathy | 279 | 219 (78.5) | 87 | 57 (65.5) | 32 | 21 (65.6) | 0.012 |
| Spleen diameter (mm) | 140 | 145 (130–160) | 37 | 155 (140–167) | 19 | 167 (143–171) | <0.001 |
| Splenomegaly (>14 cm) | 140 | 77 (55.0) | 37 | 27 (73.0) | 19 | 16 (84.2) | 0.003 |
| Previous corticosteroid therapy | 278 | 22 (7.9) | 86 | 4 (4.7) | 32 | 0 (0.0) | 0.060 |
| Hospital stay (days) | 281 | 5 (4–7) | 87 | 6 (4–8) | 32 | 9 (7–12) | <0.001 |
| Death during admission | 281 | 0 (0.0) | 87 | 2 (2.3) | 32 | 1 (3.1) | 0.008 |
| Positive heterophile antibody test | 270 | 248 (91.9) | 81 | 69 (85.2) | 29 | 21 (72.4) | <0.001 |
| Serum bilirubin (mg/dL) | 272 | 0.7 (0.4–1.3) | 84 | 1.2 (0.8–2.7) | 32 | 1.2 (0.6–1.8) | <0.001 |
| Prothrombin time (INR) | 184 | 1.06 (1.01–1.14) | 58 | 1.12 (1.06–1.20) | 19 | 1.12 (1.05–1.23) | <0.001 |
| Serum ALT (times the ULN) | 279 | 6.7 (3.2–10.5) | 87 | 7.3 (2.9–11.6) | 32 | 4.7 (1.9–11.1) | 0.335 |
| Blood hemoglobin (g/dL) | 281 | 13.5 (12.3–14.5) | 87 | 13.7 (12.6–14.8) | 32 | 13.4 (12.7–15.1) | 0.115 |
| Anemia * | 281 | 66 (23.5) | 87 | 20 (23.0) | 32 | 7 (21.9) | 0.835 |
| Blood leukocytes (×109/L) | 281 | 12.9 (8.8–17.1) | 87 | 10.2 (5.8–14.4) | 32 | 6.3 (3.1–11.4) | <0.001 |
| Blood lymphocytes (%) | 281 | 53 (44–61) | 87 | 53 (39–62) | 32 | 37 (21–56) | 0.011 |
| Serum IgG (mg/dL) | 177 | 1390 (1150–1630) | 53 | 1200 (1030–1370) | 27 | 1130 (1025–1600) | <0.001 |
| Serum IgA (mg/dL) | 177 | 295 (207–378) | 53 | 256 (170–330) | 27 | 211 (171–361) | 0.015 |
| Serum IgM (mg/dL) | 177 | 240 (183–338) | 53 | 243 (158–332) | 27 | 188 (145–260) | 0.086 |
Figures are medians and interquartile ranges (within parentheses) or absolute numbers and percentages (within parentheses). No., number of patients with available determination. P-values were obtained with a trend test (chi-square test for categorical variables and Jonckheere-Terpstra test for numerical variables). INR, International Normalized Ratio; ALT, alanine aminotransferase; ULN, upper limit of normal.
*
Blood hemoglobin <12 g/dL (females) or <13 g/dL (males).