Table 2.
Functional analysis (gene set enrichment anaysis for biological process terms) of genes that are positively regulated by NR3C1 in breast cancer.
| Common GO-BP Terms | Significant Terms | Microarray (n = 10,455) | RNAseq (n = 4421) | ||
|---|---|---|---|---|---|
| p-Value | Associated Genes | p-Value | Associated Genes | ||
| positive regulation of cell migration | GO:0030335 | 2.8 × 10−5 | CAV1, CXCL12, IGF1, PECAM1, S1PR1 | 5.63 × 10−6 | CAV1, CDH5, CXCL12, DAB2, F10, F2R, FAM107A, FER, HGF, IGF1, KDR, PDGFD, PDGFRA, PECAM1, PPM1F, PRKCA, S1PR1, SEMA3G, SEMA5A, SPRY2, VSIR |
| positive regulation of smooth muscle cell proliferation | GO:0048661 | 1.18 × 10−4 | IGF1, S1PR1, TGFBR2 | 2.02 × 10−3 | CALCRL, IGF1, IL6R, PDGFD, S1PR1, TGFBR2, TLR4 |
| intracellular steroid hormone receptor signaling pathway | GO:0030518 | 1.3 × 10−4 | NR3C1, PLPP1 | 3.67 × 10−3 | NR3C1, NR3C2, PLPP1 |
| positive regulation of peptidyl-tyrosine phosphorylation | GO:0050731 | 3.9 × 10−4 | ENPP2, IGF1, PECAM1 | 3.53 × 10−4 | ANGPT4, BMP6, ENPP2, FGF7, HGF, IGF1, IL6R, NRP1, PECAM1, RELN |
| maintenance of blood–brain barrier | GO:0035633 | 1.11 × 10−3 | JAM2, PECAM1GO:0010634 | 2.61 × 10−6 | CDH5, CLDN5, DMD, JAM2, JAM3, LAMA2, MBP, PECAM1 |
| cellular response to transforming growth factor beta stimulus | GO:0071560 | 3.47 × 10−3 | CAV1, NR3C1 | 3.34 × 10−5 | ACVRL1, CAV1, FYN, MEF2C, NR3C1, PDE2A, PDE3A, PDGFD, ZFP36L2 |
| vasculogenesis | GO:0001570 | 3.98 × 10−3 | CAV1, TGFBR2 | 8.86 × 10−6 | CAV1, ENG, HEG1, KDR, MYOCD, QKI, SOX17, TGFBR2, TIE1, TMEM100 |
| glomerular endothelium development | GO:0072011 | 4.79 × 10−3 | PECAM1 | 2.63 × 10−3 | CD34, PECAM1 |
| regulation of membrane repolarization during action potential | GO:0098903 | 4.79 × 10−3 | CAV1 | 2.63 × 10−3 | CACNA2D1, CAV1 |
| signal transduction | GO:0007165 | 6.15 × 10−3 | CXCL12, IGF1, NR3C1, PECAM1, PLPP1, SPARCL1 | 9.17 × 10−3 | AKAP13, DLC1, KANK2, STARD8 |
| myotube cell development | GO:0014904 | 6.38 × 10−3 | IGF1 | 5.15 × 10−3 | IGF1, NFATC2 |
| monocyte extravasation | GO:0035696 | 6.38 × 10−3 | PECAM1 | 5.15 × 10−3 | CCR2, PDGFD |
| diapedesis | GO:0050904 | 6.38 × 10−3 | PECAM1 | 5.15 × 10−3 | FER, PECAM1 |
| myoblast proliferation | GO:0051450 | 6.38 × 10−3 | IGF1 | 1.04 × 10−4 | ATOH8, HGF, IGF1 |
| caveola assembly | GO:0070836 | 7.97 × 10−3 | CAV1 | 8.41 × 10−3 | CAV1, CAV2 |
| hematopoietic stem cell migration to bone marrow | GO:0097241 | 7.97 × 10−3 | JAM2 | 8.41 × 10−3 | JAM2, JAM3 |
| positive regulation of epithelial–mesenchymal transition involved in endocardial cushion formation | GO:1905007 | 7.97 × 10−3 | TGFBR2 | 8.41 × 10−3 | ENG, TGFBR2 |
| receptor-mediated endocytosis of virus by host cell | GO:0019065 | 9.55 × 10−3 | CAV1 | 1.13 × 10−5 | CAV1, CAV2, EPS15, PIKFYVE |
| cellular response to hyperoxia | GO:0071455 | 9.55 × 10−3 | CAV1 | 4.98 × 10−4 | CAV1, FAS, FOXO1 |
| neutrophil extravasation | GO:0072672 | 9.55 × 10−3 | PECAM1 | 4.98 × 10−4 | JAML, PECAM1, PIK3CG |