Table 2.
Frequencies functional mutations groups in global cohort and grouped by age.
| Functional Mutations Group n (%) | Mutations | Cohort (n = 130) |
<60 Years (n = 49) |
≥60 Years (n = 81) |
p |
|---|---|---|---|---|---|
| Signaling pathways | FLT3, KRAS, NRAS, KIT, PTPN | 47 (36.1) | 23 (46.9) | 24 (29.6) | 0.03 |
| Epigenetic modification | |||||
| DNA methylation | DNMT3A, IDH1/2, TET2 | 60 (46.1) | 22 (44.8) | 38 (46.9) | 0.92 |
| Chromatin modifiers | ASXL1, EZH2 y MLL/KMT2A | 19 (14.6) | 3 (6.1) | 16 (19.7) | 0.04 |
| Nucleophosmin | NPM1 | 23 (17.7) | 14 (28.5) | 9 (11.1) | <0.01 |
| Transcription factors | CEBPA, RUNX1 y GATA2 | 24 (18.5) | 7 (14.3) | 17 (21) | 0.37 |
| Tumor Suppressors | TP53 | 25 (19.2) | 5 (10.2) | 20 (24.6) | 0.05 |
| Spliceosome complex | SRSF2, U2AF1, SF3B1 y ZRSR2 | 32 (24.6) | 3 (6.1) | 29 (35.8) | <0.01 |
| Fusiontranscription factors | RUNX1/RUNX1T, MYH11/CBF | 8 (6.1) | 6 (12.3) | 2 (2.5) | 0.02 |