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. 2023 Feb 27;15(5):1498. doi: 10.3390/cancers15051498

Figure 2.

Figure 2

Principal molecular pathways for GISTs and sites of action of specific pathways’ inhibitors. Green boxes indicate kinases with gain-of-function mutations (RAS, BRAF, and PI3K genes); orange boxes indicate proteins with loss-of-function (mutations in the NF1 gene and loss of function of the SDH complex—either loss of function mutations in genes coding for SDH subunits or epigenetic silencing of the SDHC gene). TF—transcription factor; ETV1—ETS variant transcription factor 1; RTK—receptor tyrosine kinase; TKI—tyrosine kinase inhibitor; DNA—deoxyribonucleic acid.