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Clinical variants of multiple system atrophy.
| Clinical Subtype | Main Motor Feature | Pathological Distribution |
|---|---|---|
| MSA-P | Parkinsonism | Nigrostriatal atrophy |
| MSA-C | Limb and gait ataxia | Olivopontocerebellar atrophy |
| Mixed subtype | Both motor features | Combined atrophy |
| MSA-autonomic failure | No motor features | Central autonomic brain regions |
| MSA-dementia | No motor features | Frontotemporal plus combined atrophy |
