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Development of the DC autologous vaccines. The DC vaccines are most commonly prepared by ex vivo differentiation of the autologous monocytes into immature DCs. After maturation, DCs are pulsed with cancer antigens and administered back to the patient, where they activate antigen-specific T cells. CSC—cancer stem cells; MHC I and MHC II—major histocompatibility complex class I and class II; PBMC—peripheral blood mononuclear cells; TAA—tumor-associated antigen. Created with BioRender.
