Table 1.
A list of HIF-1α-interacting HIF-1 co-regulators with their effectors.
| HIFα Isoform | HIF-1α Domain (Residues) Involved |
Co-Regulators | Effectors | Ref. | Cell Types |
|---|---|---|---|---|---|
| Acetyl transferases | |||||
| HIF-1α | N-TAD (532–585) C-TAD (776–826) |
p300/CBP (+) | [25,26,27,28] | HEK293, HeLa, Hep3B, HCT166 |
|
| HIF-1α/2α | Asn-803/847 | FIH-1 (−) | [29,30,31] | HEK293, Hep3B | |
| HIF-1α | Lys-674 | SIRT1 (−) PCAF (+) | [32] | HEK293, Hep3B, HT1080 | |
| HIF-1α | ND | SRC-1 (+) Ref-1 (+) |
[33] | HEK293, COS7 | |
| HIF-1α | ND | #MUC1 (+) | [34] | Pancreatic cancer | |
| HIF-1α | C-TAD | #PKA (+) | [35] | HeLa, cardiomyocytes | |
| HIF-1α | N-term. (1–400) | FABP5 (+) | [36] | HEK293, HepG2 | |
| HIF-1α | C-TAD | #CITED2 (−) | [37,38] | Hep3B | |
| HIF-1α | ODD/N-TAD (429–608) |
FHL2 (−) | [39] | HEK293, Hep3B | |
| HIF-1α/2α | C-TAD | FGFR2 (−) | [40] | DU145, PC3 | |
| HIF-1α | C-TAD | EAF2 (−) | [41] | HEK293, ccRCC | |
| HIF-1α | Reptin (−) | #G9a (+) | [42] | MCF7 | |
| HIF-1α | ND | Pontin (+) |
#G9a (+) GLP (+) |
[43] | MCF7 |
| HIF-1α | TIP60 (+) | [44] | HCT116 | ||
| Methylation/demethylation enzymes | |||||
| HIF-1α | C-term. (575–826) | # JMJD2C (+) | [45] | HeLa, MDA-MB-435 | |
| HIF-1α | bHLH (17–70) | # JMJD1A (+) | [46,47] | HUVEC, UBC | |
| HIF-1α/2α | PAS-B (175–305) | #TET1 (+) | [48,49] | HEK293, H1299, FADU | |
| HIF-1α | ND | SET9 (+) | [50] | HEK293, Hep3B, U2OS | |
| HIF-1α/2α | N-term. (1–396) | SET1B (+) | [51] | HeLa, A549 | |
| Other epigenetic enzymes & Epigenetic readers | |||||
| HIF-1α/2α | ND | # PADI4 (+) | [52] | Breast cancer, Hepatoma | |
| HIF-1α/2α | ND | # ZMYND8 (+) | p300 (+) | [53] | Breast cancer |
| Transcriptional machinery | |||||
| HIF-1α | C-TAD | CDK8- Mediator (+) |
AFF4 (+) CDK9 (+) |
[54] | HCT116 |
| HIF-1α/2α | C-term. (531–826) | TRIM28 (+) | CDK9 (+) | [55] | Breast cancer |
| Chromatin remodeling factors | |||||
| HIF-1α/2α | ND | BRG1 (+) | [56] | HEK293, Hep3B | |
| HIF-1α/2α | C-term. (531–826) | CHD4 (+) | p300 (+) | [57] | Breast cancer |
| HIF-1α | ETD (616–658) Ser641/643 |
# NPM1 (+) | ERK1/2 (+) | [58] | HeLa, Huh7 |
| Other proteins | |||||
| HIF-1α/2α | C-term. (531–826) | #PKM2 (+) | PHD3 (+) | [59] | HeLa, Hep3B, RCC4 |
| JMJD5 (+) | [60] | HeLa, MCF7 | |||
| Digoxin (−) | [61] | Macrophages | |||
| [62,63] | Macrophages | ||||
| HIF-1α/2α | C-term./ID (604–726) | FBP1 (−) | [64] | HEK293, ccRCC, HK-2, A549 | |
| HIF-1α/2α | ND | PARP1 (+) | [65] | K562, MLF | |
| HIF-1α | N-term. (1–390) | Filamin A (+) | [66] | Melanoma, HeLa NIH 3T3, COS1, HEK293, U2OS | |
(−)/(+) denote negative/positive co-regulator or effector; # denotes HIF-1 direct target; ND: Not Determined.