Table 1.
Baseline characteristics of all H. pylori-treated patients.
| Characteristics | Family History of GC (n = 294,706) |
No Family History of GC (n = 1,594,109) |
p-Value |
|---|---|---|---|
| Age at screening (years) | 57.1 ± 9.7 | 57.1 ± 9.8 | <0.001 |
| Age group at screening | |||
| 40–49 years | 66,376 (22.5) | 367,285 (23.0) | <0.001 |
| 50–59 years | 109,451 (37.1) | 579,176 (36.3) | |
| 60–69 years | 82,100 (27.9) | 440,026 (27.6) | |
| ≥70 years | 36,779 (12.5) | 207,622 (13.0) | |
| Sex | |||
| Female | 123,644 (42.0) | 613,556 (38.5) | <0.001 |
| Male | 171,062 (58.0) | 980,553 (61.5) | |
| Obesity (BMI ≥ 25 kg/m2) | |||
| No | 190,779 (64.7) | 1,021,777 (64.1) | <0.001 |
| Yes | 103,902 (35.3) | 572,168 (35.9) | |
| Unknown | 25 (0.0) | 164 (0.0) | |
| Smoking habit | |||
| Never | 195,926 (66.5) | 1,115,474 (70.0) | <0.001 |
| Former | 51,370 (17.4) | 232,825 (14.6) | |
| Current | 47,309 (16.1) | 245,282 (15.4) | |
| Unknown | 101 (0.0) | 528 (0.0) | |
| Alcohol consumption | |||
| 0 or 1 time per week | 227,576 (77.2) | 1,252,957 (78.6) | <0.001 |
| ≥2 times per week | 66,897 (22.7) | 340,069 (21.3) | |
| Unknown | 233 (0.1) | 1083 (0.1) | |
| Physical activity | |||
| No | 66,836 (22.7) | 394,668 (24.8) | <0.001 |
| Yes (≥1 time per week) | 227,552 (77.2) | 1,197,894 (75.2) | |
| Unknown | 318 (0.1) | 1547 (0.1) | |
| Comorbidities | |||
| Hypertension | 80,762 (27.4) | 462,299 (29.0) | <0.001 |
| Diabetes mellitus | 30,353 (10.3) | 170,240 (10.7) | |
| Dyslipidemia | 23,646 (8.0) | 120,842 (7.6) | |
| Ischemic heart disease | 11,569 (3.9) | 61,131 (3.8) | |
| Stroke | 3656 (1.2) | 19,605 (1.2) | |
| Comorbidity status (yes) | 108,743 (36.9) | 606,308 (38.0) | <0.001 |
| Indication for H. pylori eradication | |||
| Gastric ulcer | 61,147 (20.7) | 320,248 (20.1) | <0.001 |
| Duodenal ulcer | 15,229 (5.2) | 79,547 (5.0) | |
| Gastric and duodenal ulcer a | 13,469 (4.6) | 74,606 (4.7) | |
| Gastric MALT lymphoma | 4 (0.0) | 3 (0.0) | |
| H. pylori-associated gastritis | 204,857 (69.5) | 1,119,705 (70.2) |
GC, gastric cancer; BMI, body mass index; H. pylori, Helicobacter pylori; MALT, mucosa-associated lymphoid tissue. Values are presented as mean ± standard deviation or number (%). a Gastric ulcer and duodenal ulcer/ gastroduodenal ulcer unspecified.