Table 2.
Risk of gastric cancer according to age at H. pylori eradication in patients with a family history of gastric cancer.
| Variables | N | Person–Years | Incidence (95% CI) a |
Crude HR (95% CI) | Adjusted HR (95% CI) |
|---|---|---|---|---|---|
| Age at H. pylori eradication | |||||
| ≥75 years | 214 | 45,998 | 4.65 (4.03–5.28) | 1 (Reference) | 1 (Reference) |
| 70–74 years | 287 | 69,429 | 4.13 (3.66–4.61) | 0.89 (0.75–1.06) | 0.98 (0.79–1.21) |
| 65–69 years | 553 | 172,833 | 3.20 (2.93–3.47) | 0.69 (0.59–0.81) | 0.88 (0.74–1.05) |
| 60–64 years | 396 | 162,193 | 2.44 (2.20–2.68) | 0.52 (0.44–0.62) | 0.76 (0.59–0.99) |
| 55–59 years | 544 | 314,374 | 1.73 (1.59–1.88) | 0.37 (0.32–0.44) | 0.62 (0.44–0.88) |
| 50–54 years | 311 | 225,437 | 1.38 (1.23–1.53) | 0.30 (0.25–0.35) | 0.57 (0.36–0.90) |
| 45–49 years | 157 | 187,873 | 0.84 (0.70–0.97) | 0.18 (0.15–0.22) | 0.38 (0.22–0.66) |
| 40–44 years | 148 | 229,125 | 0.65 (0.54–0.75) | 0.14 (0.11–0.17) | 0.34 (0.17–0.67) |
| p for trend | <0.001 | <0.001 | |||
| Age at screening, per year | 1.06 (1.06–1.06) | 1.03 (1.01–1.05) | |||
| Sex | |||||
| Female | 970 | 822,475 | 1.18 (1.11–1.25) | 1 (Reference) | 1 (Reference) |
| Male | 1640 | 584,787 | 2.80 (2.67–2.94) | 2.37 (2.19–2.57) | 2.09 (1.88–2.34) |
| Obesity (BMI ≥ 25 kg/m2) | |||||
| No | 1681 | 910,886 | 1.85 (1.76–1.93) | 1 (Reference) | 1 (Reference) |
| Yes | 928 | 496,257 | 1.87 (1.75–1.99) | 1.01 (0.94–1.10) | 0.95 (0.87–1.03) |
| Smoking habit | |||||
| Never | 1348 | 940,476 | 1.43 (1.36–1.51) | 1 (Reference) | 1 (Reference) |
| Former | 700 | 243,307 | 2.88 (2.66–3.09) | 2.00 (1.83–2.19) | 1.17 (1.04–1.31) |
| Current | 561 | 222,999 | 2.52 (2.31– 2.72) | 1.75 (1.59–1.93) | 1.38 (1.22–1.56) |
| Alcohol consumption | |||||
| 0 or 1 time/week | 1869 | 1,089,055 | 1.72 (1.64–1.79) | 1 (Reference) | 1 (Reference) |
| ≥2 times/week | 740 | 317,127 | 2.33 (2.17–2.50) | 1.36 (1.25–1.48) | 1.08 (0.98–1.19) |
| Physical activity | |||||
| No | 603 | 320,047 | 1.88 (1.73–2.03) | 1 (Reference) | 1 (Reference) |
| Yes (≥1 time/week) | 2000 | 1,085,671 | 1.84 (1.76–1.92) | 0.98 (0.89–1.07) | 0.97 (0.88–1.06) |
| Comorbidity status b | |||||
| No | 1353 | 887,775 | 1.52 (1.44–1.61) | 1 (Reference) | 1 (Reference) |
| Yes | 1257 | 519,487 | 2.42 (2.29–2.55) | 1.59 (1.47–1.72) | 1.03 (0.95–1.12) |
H. pylori, Helicobacter pylori; CI, confidence interval; HR, hazard ratio; BMI, body mass index. a Incidence rate was calculated as cases per 1000 person–years. b Comorbidity status was defined as having at least one of hypertension, diabetes mellitus, dyslipidemia, ischemic heart disease, and stroke.