Table 5.

Risk of gastric adenoma according to the age at H. pylori eradication in total study population and the patients with and without family history of gastric cancer.

Variables	N	Crude HR (95% CI)	Adjusted HR a (95% CI)
Total
Age at H. pylori eradication	n = 6899
≥60 years	3756	1 (Reference)	1 (Reference)
55–59 years	1292	0.64 (0.60–0.68)	0.72 (0.66–0.78)
50–54 years	1130	0.47 (0.44–0.51)	0.56 (0.50–0.63)
45–49 years	439	0.29 (0.26–0.32)	0.35 (0.30–0.41)
40–44 years	282	0.14 (0.13–0.16)	0.18 (0.15–0.22)
p for trend		<0.001	<0.001
With family history
Age at H. pylori eradication	n = 1450
≥60 years	775	1 (Reference)	1 (Reference)
55–59 years	264	0.62 (0.54–0.71)	0.68 (0.56–0.82)
50–54 years	251	0.49 (0.43–0.57)	0.57 (0.45–0.73)
45–49 years	96	0.29 (0.24–0.36)	0.35 (0.25–0.49)
40–44 years	64	0.16 (0.12–0.21)	0.20 (0.13–0.31)
p for trend		<0.001	<0.001
Without family history
Age at H. pylori eradication	n = 5449
≥60 years	2981	1 (Reference)	1 (Reference)
55–59 years	1028	0.65 (0.60–0.69)	0.73 (0.66–0.80)
50–54 years	879	0.47 (0.43–0.50)	0.56 (0.49–0.63)
45–49 years	343	0.28 (0.25–0.32)	0.35 (0.30–0.42)
40–44 years	218	0.14 (0.12–0.16)	0.18 (0.15–0.22)
p for trend		<0.001	<0.001

H. pylori, Helicobacter pylori; HR, hazard ratio; CI, confidence interval; ^a Hazard ratios from multivariate model were adjusted for age at screening, sex, obesity, smoking habit, alcohol consumption, physical activity, and comorbidities. Regression model for total population was additionally adjusted for family history of gastric cancer status.