Table 6.
Risk of gastric cancer according to age at H. pylori eradication by age group.
| Age at H. pylori Eradication a | Total Population | With Family History | Without Family History | ||||
|---|---|---|---|---|---|---|---|
| HR (95% CI) b | p c | HR (95% CI) b | p c | HR (95% CI) b | p c | ||
| 40–44 | Age 44→45 | Ref. | <0.001 | Ref. | 0.353 | Ref. | <0.001 |
| Age 43→45 | 0.98 (0.75–1.29) | 1.24 (0.71–2.16) | 0.91 (0.67–1.25) | ||||
| Age 42→45 | 0.86 (0.67–1.11) | 0.83 (0.48–1.43) | 0.87 (0.66–1.15) | ||||
| Age 41→45 | 0.78 (0.58–1.06) | 1.16 (0.64–2.09) | 0.68 (0.47–0.97) | ||||
| Age 40→45 | 0.70 (0.56–0.86) | 0.85 (0.54–1.34) | 0.66 (0.52–0.83) | ||||
| 45–49 | Age 49→50 | Ref. | 0.308 | Ref. | 0.693 | Ref. | 0.345 |
| Age 48→50 | 1.09 (0.89–1.33) | 1.10 (0.68–1.75) | 1.09 (0.87–1.36) | ||||
| Age 47→50 | 1.15 (0.92–1.44) | 1.14 (0.68–1.92) | 1.15 (0.89–1.48) | ||||
| Age 46→50 | 0.88 (0.71–1.10) | 0.96 (0.59–1.57) | 0.86 (0.68–1.10) | ||||
| Age 45→50 | 0.96 (0.76–1.23) | 0.91 (0.52–1.62) | 0.98 (0.75–1.28) | ||||
| 50–54 | Age 54→55 | Ref. | <0.001 | Ref. | 0.120 | Ref. | <0.001 |
| Age 53→55 | 0.84 (0.72–0.98) | 0.88 (0.65–1.20) | 0.83 (0.70–0.98) | ||||
| Age 52→55 | 0.80 (0.70–0.91) | 0.83 (0.64–1.09) | 0.79 (0.68–0.92) | ||||
| Age 51→55 | 0.79 (0.68–0.92) | 0.77 (0.56–1.06) | 0.80 (0.67–0.95) | ||||
| Age 50→55 | 0.75 (0.65–0.86) | 0.83 (0.63–1.09) | 0.73 (0.63–0.86) | ||||
| 55–59 | Age 59→60 | Ref. | <0.001 | Ref. | 0.022 | Ref. | <0.001 |
| Age 58→60 | 0.88 (0.76–1.01) | 0.88 (0.66–1.17) | 0.88 (0.75–1.02) | ||||
| Age 57→60 | 0.85 (0.73–0.98) | 0.76 (0.55–1.06) | 0.87 (0.73–1.03) | ||||
| Age 56→60 | 0.78 (0.68–0.90) | 0.79 (0.60–1.06) | 0.78 (0.67–0.91) | ||||
| Age 55→60 | 0.71 (0.60–0.83) | 0.67 (0.48–0.94) | 0.72 (0.60–0.86) | ||||
| 60–64 | Age 64→65 | Ref. | <0.001 | Ref. | 0.001 | Ref. | 0.005 |
| Age 63→65 | 0.85 (0.75–0.97) | 0.86 (0.66–1.12) | 0.85 (0.74–0.99) | ||||
| Age 62→65 | 0.89 (0.79–0.99) | 0.80 (0.64–1.01) | 0.91 (0.80–1.03) | ||||
| Age 61→65 | 0.78 (0.68–0.89) | 0.75 (0.57–0.99) | 0.79 (0.67–0.91) | ||||
| Age 60→65 | 0.82 (0.73–0.91) | 0.68 (0.54–0.86) | 0.86 (0.76–0.97) | ||||
| 65–69 | Age 69→70 | Ref. | 0.039 | Ref. | 0.150 | Ref. | 0.113 |
| Age 68→70 | 0.85 (0.75–0.97) | 0.84 (0.61–1.14) | 1.10 (0.94–1.30) | ||||
| Age 67→70 | 0.89 (0.79–0.99) | 0.78 (0.55–1.12) | 1.00 (0.83–1.20) | ||||
| Age 66→70 | 0.78 (0.68–0.89) | 0.81 (0.60–1.10) | 0.95 (0.80–1.12) | ||||
| Age 65→70 | 0.82 (0.73–0.91) | 0.73 (0.52–1.03) | 0.92 (0.77–1.10) | ||||
| 70–74 | Age 74→75 | Ref. | 0.079 | Ref. | 0.149 | Ref. | 0.234 |
| Age 73→75 | 1.04 (0.90–1.20) | 1.09 (0.75–1.60) | 0.93 (0.75–1.15) | ||||
| Age 72→75 | 0.95 (0.80–1.11) | 1.05 (0.76–1.45) | 0.97 (0.82–1.16) | ||||
| Age 71→75 | 0.92 (0.79–1.06) | 0.87 (0.59–1.26) | 0.85 (0.70–1.03) | ||||
| Age 70→75 | 0.88 (0.75–1.02) | 0.85 (0.62–1.16) | 0.89 (0.76–1.05) | ||||
| ≥75 | Age ≥79→age + 1 d | Ref. | 0.529 | Ref. | 0.437 | Ref. | 0.739 |
| Age 78→80 | 1.10 (0.88–1.38) | 1.38 (0.84–2.25) | 1.04 (0.81–1.34) | ||||
| Age 77→80 | 0.91 (0.71–1.17) | 1.01 (0.57–1.80) | 0.89 (0.67–1.17) | ||||
| Age 76→80 | 0.99 (0.81–1.20) | 1.33 (0.87–2.03) | 0.91 (0.73–1.14) | ||||
| Age 75→80 | 0.96 (0.77–1.18) | 0.65 (0.38–1.14) | 1.03 (0.81–1.29) | ||||
HR, hazard ratio; CI, confidence interval; a Participants within an age group were followed up until all reached comparable age. b Hazard ratios from multivariate model were adjusted for sex, obesity, smoking habit, alcohol consumption, physical activity, and comorbidity status. Regression model for total population was additionally adjusted for family history of gastric cancer status. c p for trend. d There was no age-limitation for age at H. pylori eradication; thus, for those who received H. pylori eradication at an age ≥79, the follow-up period was set to 1 year (age + 1). For example, people who received H. pylori eradication at the age of 82, the follow-up period was set to 1 year (up to the age of 83).