Table 2.
Summarized table of various mutations/chromosomal alterations in components of NF-κB pathway affecting its expression and activity in different cancer types.
| Factors/Regulators of NF-κB Pathway | Type of Mutation/Chromosomal Translocation | Cancer Type | Response | References |
|---|---|---|---|---|
| TRAF3 | Bi-allelic deletion at 14q32 | MM | Increased p52/p100 ratios | [91,177] |
| TRAF2 | Bi-allelic deletion at 9q34 | MM | Increased p52/p100 ratios | [91,177] |
| CYLD | Bi-allelic deletion at 16q12 | MM | Increased p52/p100 ratios | [91,177] |
| cIAP1/cIAP2 | Bi-allelic deletion at 11q22 | MM | Increased p52/p100 ratios | [91,177] |
| NIK | t(17;22) translocation, IgH translocation or amplification | MM | Overexpression of NIK | [93] |
| LTBR | amplification of the entire 12p chromosome arm | MM | Activatory | [91] |
| NF-κB2 | t(10;14)(q24;q32) t(10q24) |
MALT Lymphoma, DLBCL |
Activatory, Enhanced expression of NF-κB2 gene and protein |
[15,91,153] |
| AP12-MALT1 | t(11;18)(q21;q21) | B-cell Lymphoma, MALT lymphoma | Activatory | [154,155] |
| c-Rel | t(2p 13-15) | DLBCL, B-cell lymphoma, Follicular large cell lymphoma | Enhanced amplification of c-Rel gene | [120,121,149,159,161] |
| RelA | (11q13) site with t(11;14)(q13;q32) | NHL, Diffuse large cell lymphoma, Squamous carcinoma of head and neck, Breast cancer | Activatory | [159,162] |
| Bcl3 | t(14;19)(q32;q13.1) | B-cell leukaemia | Activatory | [163] |