Table 1.
Demographic, clinical and MRI data at the baseline MRI.
| Variable | All Patients | No HF Death | HF Death | p-Value |
|---|---|---|---|---|
| Women, N (%) | 725 (51.9%) | 719 (51.9%) | 6 (50.0%) | 0.897 |
| Age (years) | 30.84 ± 8.91 | 30.82 ± 8.92 | 33.38 ± 7.96 | 0.276 |
| Age at start of regular transfusions (years) | 2.24 ± 3.77 | 2.25 ± 3.78 | 1.40 ± 1.26 | 0.388 |
| Chelation starting age (years) | 4.69 ± 4.08 | 4.69 ± 4.08 | 4.67 ± 4.63 | 0.716 |
| Pre-transfusion hemoglobin (g/dL) | 9.58 ± 0.68 | 9.59 ± 0.68 | 9.13 ± 1.14 | 0.328 |
| Serum ferritin (ng/mL) | 1506.01 ± 476.65 | 1491.66 ± 1447.64 | 4589.17 ± 3607.63 | 0.012 |
| Global heart T2* (ms) | 29.46 ± 12.03 | 29.57 ± 11.97 | 17.50 ± 12.91 | 0.002 |
| Number of segments with T2* < 20 ms | 4.47 ± 6.09 | 4.43 ± 6.07 | 10.08 ± 6.30 | 0.002 |
| MR LIC (mg/g/dw) | 8.89 ± 10.87 | 8.81 ± 10.76 | 19.96 ± 16.98 | 0.009 |
| LV EF (%) | 61.58 ± 7.09 | 61.67 ± 6.89 | 51.41 ± 16.57 | 0.020 |
| RV EF (%) | 61.37 ± 8.14 | 61.47 ± 7.95 | 49.47 ± 16.98 | 0.009 |
| LV EDVI (mL/m2) | 86.60 ± 18.71 | 86.53 ± 18.53 | 95.03 ± 33.85 | 0.696 |
| RV EDVI (mL/m2) | 82.59 ± 18.73 | 82.51 ± 18.40 | 91.16 ± 29.49 | 0.414 |
| LV cardiac index (L/min/m2) | 3.68 ± 1.07 | 3.69 ± 1.07 | 3.53 ± 0.85 | 0.369 |
| Replacement myocardial fibrosis, N (%) | 187/1112 (16.8) | 182/1101 (16.5) | 5/11 (45.5) | 0.025 |
| Left atrial area (cm2/m2) | 12.94 ± 2.65 | 12.93 ± 2.63 | 14.90 ± 4.06 | 0.139 |
| Right atrial area (cm2/m2) | 12.02 ± 2.35 | 12.02 ± 2.35 | 12.67 ± 1.92 | 0.264 |
N = number, MRI = magnetic resonance imaging, LIC = liver iron concentration, LV = left ventricular, EF = ejection fraction; RV = right ventricular, EDVI = end-diastolic volume index.