Table 2.
Results of univariate Cox analysis for heart failure mortality.
| N (%) in Group | N (%) with HF | Univariate Analysis | ||
|---|---|---|---|---|
| HR (95%CI) | p | |||
| Sex | ||||
| Male | 673 (48.1) | 6 (0.9) | Reference | |
| Female | 725 (51.9) | 6 (0.8) | 0.93 (0.29–2.87) | 0.893 |
| Age | ||||
| <31 years | 645 (46.1) | 4 (0.6) | Reference | |
| ≥31 years | 753 (53.9) | 8 (1.1) | 1.73 (0.52–5.75) | 0.371 |
| Serum ferritin | ||||
| <1000 ng/mL | 667 (47.3) | 3 (0.4) | Reference | |
| ≥1000 ng/mL | 731 (52.3) | 9 (1.2) | 4.58 (0.54–39.17) | 0.165 |
| MRI LIC | ||||
| <3 mg/g dw | 512 (36.6) | 2 (0.4) | Reference | |
| ≥3 mg/g dw | 886 (63.4) | 10 (1.1) | 2.89 (0.63–13.19) | 0.171 |
| Global heart T2* | ||||
| ≥20 ms | 1042 (74.5) | 5 (0.5) | Reference | |
| <20 ms | 356 (9.7) | 7 (2.0) | 4.04 (1.28–12.75) | 0.017 |
| Ventricular dysfunction | ||||
| no | 978 (70.0) | 5 (0.5) | Reference | |
| yes | 420 (30.0) | 7 (1.7) | 3.30 (1.05–10.41) | 0.041 |
| Ventricular dilatation | ||||
| no | 1301 (93.1) | 8 (0.6) | Reference | |
| yes | 97 (6.9) | 4 (4.1) | 6.63 (1.99–22.04) | 0.002 |
| Myocardial fibrosis (N = 1112) | ||||
| no | 925 (83.2) | 6 (0.6) | Reference | |
| yes | 187 (16.8) | 5 (2.7) | 4.19 (1.28–13.72) | 0.018 |
| Atrial dilatation (N = 1138) | ||||
| no | 890 (78.2) | 6 (0.7) | Reference | |
| yes | 248 (21.8) | 3 (1.2) | 1.77 (0.44–7.09) | 0.417 |
N = number, HF = heart failure, HR = hazard ratio, CI = confidence intervals, MRI = magnetic resonance imaging; LIC = liver iron concentration.