Table 3.
Comparison of the three groups identified on the basis of the number of CMR abnormalities.
| Variable | No CMR Abnormalities (N = 488) |
One to Three CMR Abnormalities (N = 617) |
Four CMR Abnormalities (N = 7) |
p-Value |
|---|---|---|---|---|
| Women, N (%) | 263 (53.9%) | 308 (49.9%) | 0 (0.0%) | 0.010 |
| Age (years) | 30.56 ± 8.68 | 31.49 ± 8.24 | 32.90 ± 6.28 | 0.315 |
| Age at start of regular transfusions (years) | 2.12 ± 2.84 | 2.43 ± 4.84 | 2.50 ± 1.91 | 0.280 |
| Chelation starting age (years) | 4.43 ± 3.96 | 4.81 ± 4.14 | 4.00 ± 2.12 | 0.313 |
| Pre-transfusion hemoglobin (g/dL) | 9.58 ± 0.58 | 9.61 ± 0.77 | 9.27 ± 0.52 | 0.335 |
| Serum ferritin (ng/mL) | 1283.28 ± 1148.91 | 1681.25 ± 1669.89 | 1359.50 ± 945.66 | 0.001 |
| Global heart T2* (ms) | 35.17 ± 6.68 | 24.49 ± 12.89 | 10.01 ± 2.37 | <0.0001 |
| Number of segments with T2* < 20 ms | 1.17 ± 1.99 | 7.13 ± 6.90 | 15.29 ± 0.76 | <0.0001 |
| MR LIC (mg/g/dw) | 6.86 ± 7.49 | 10.54 ± 13.14 | 9.51 ± 7.69 | <0.0001 |
| LV EF (%) | 64.87 ± 5.13 | 59.11 ± 7.18 | 40.16 ± 12.32 | <0.0001 |
| RV EF (%) | 64.83 ± 5.73 | 58.66 ± 8.40 | 40.73 ± 13.21 | <0.0001 |
| LV EDVI (mL/m2) | 84.16 ± 15.98 | 89.80 ± 20.32 | 136.14 ± 23.09 | <0.0001 |
| RV EDVI (mL/m2) | 80.95 ± 15.38 | 85.71 ± 20.21 | 130.39 ± 16.57 | <0.0001 |
| LV cardiac index (L/min/m2) | 3.83 ± 1.05 | 3.59 ± 1.08 | 3.72 ± 0.41 | <0.0001 |
| Replacement myocardial fibrosis, N (%) | 0 (0.0) | 180 (29.2) | 7 (100.0) | <0.0001 |
| Left atrial area (cm2/m2) | 12.57 ± 2.37 | 13.26 ± 2.76 | 15.52 ± 2.48 | <0.0001 |
| Right atrial area (cm2/m2) | 11.73 ± 2.05 | 12.34 ± 2.53 | 13.97 ± 2.45 | 0.001 |
N = number, MRI = magnetic resonance imaging, LIC = liver iron concentration, LV = left ventricular, EF = ejection fraction; RV = right ventricular, EDVI = end-diastolic volume index.