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. 2023 Feb 22;12(5):688. doi: 10.3390/cells12050688

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© 2023 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Schematic diagram showing the proposed beneficial effects of eriodictyol. Neuro-COVID can activate mast cells, and several inflammatory mediators released from activated mast cells can activate microglia and other brain cells to release inflammatory and neurotoxic mediators that can cause neuroinflammation and neurodegeneration and exacerbate neuro-COVID disease severity. Eriodictyol could inhibit neuro-COVID-associated mast cell activation-mediated inflammatory mediator release as well as inflammatory mediators released from activated microglia. These inhibitions could reduce the disease severity or treat neuro-COVID.