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. 2023 Feb 22;12(5):688. doi: 10.3390/cells12050688

Table 1.

Mast cell actions associated with brain pathophysiology.

  • Angiogenesis

  • Activation of microglia, astrocytes, and neurons

  • Cognitive decline

  • Disruption of the BBB and entry of peripheral inflammatory mediators, cells, and pathogens/SARS CoV-2 into the brain parenchyma

  • Early responders in brain injury

  • Growth factor secretion

  • Increase vascular permeability

  • Interactions with microglia, astrocytes, and neurons

  • Neuroprotection

  • Neurodegeneration

  • Neuroinflammation

  • Proinflammatory mediator release

  • Posttraumatic stress disorder (PTSD)

  • Regulation of the HPA axis and stress response

  • Secretion of proinflammatory, neurotoxic, and vasoactive mediators

  • Vascular permeability