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. 2023 Mar 5;15(5):1612. doi: 10.3390/cancers15051612

Figure 3.

Figure 3

The mutation capture efficiency of hotSPOT for targeted sequencing panel design. (A) Difference in capture efficacy from original sequencing analysis compared to 10,000 bp sequencing panel based on training normal epidermis dataset. (B) Difference in capture efficacy from original sequencing analysis compared to 10,000 bp sequencing panel based on training cSCC dataset. (C) Difference in capture efficacy from chronically sun-exposed and intermittently sun-exposed normal epidermal samples based on 10,000 bp cSCC hotSPOT panel. Statistical significance was calculated using paired Wilcox signed-rank test. Sequencing panels based on forward hotSPOT binning algorithm. (p ≥ 0.05 ns, p < 0.05 *, p < 0.001 ***).