Table 1.

Summary of human clinically-normal epidermis and cSCC mutation datasets.

Name	Dataset	Source	Samples Sequenced	Average Sequencing Depth	Original Sequencing Panel Size	Sample Type	Panel Design
“Dataset A”	Test/Training Datasets	Fowler et al. [3]	1261	690x	0.39 Mb	Normal Epidermis (Head, forearm, leg, trunk, abdomen)	74 Cancer- related genes
“Dataset B”	Validation Dataset #1	Martincorena et al. [4]	234	374x	0.67 Mb	Normal Epidermis (Eyelid)	74 Cancer- related genes
“Dataset C”	Validation Dataset #2	Hernando et al. [2]	123	923x	0.32 Mb	Normal Epidermis (Back, chest, leg, upper arm, neck, face, hands)	46 genes frequently mutated in skin cancer
	Test/Training Datasets	Pickering et al. [6]	39	115x	-	Tumor	WES
	Validation Dataset	Inman et al. [9]	36	54x	-	Tumor	WES