Figure 5.

Expression levels of identified DEGs in human patients with inflammatory bowel diseases (ulcerative colitis and Crohn’s disease) and their association with the survival of patients with colon adenocarcinoma (COAD) and rectal adenocarcinoma (READ). (A) Heatmap demonstrating the expression levels of identified acute colitis- and CAC-related hub genes in datasets of human patients with ulcerative colitis and Crohn’s disease. The differential analysis of cDNA microarray data was performed according to Section 4.1. The heat map was constructed using Morpheus. Log₂FC = Log₂(fold change). In all datasets, biopsy samples were taken from the colon at the sites of active inflammation. (B) Survival of patients with COAD and READ depending on the expression levels of identified DEGs (TIMP1 and ADAM8) in the colon tissue. Kaplan–Meier survival curves were constructed using TCGA data according to Section 4.8. (C) The final scheme of core genes associated with acute colitis and CAC revealed in the current study, their expression profiles in murine models, and association with IBD and colorectal cancer in humans.