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. 2023 Feb 22;24(5):4351. doi: 10.3390/ijms24054351

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© 2023 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Forest plot demonstrating the effect of umbilical cord blood-derived cell therapy on (A) Astrogliosis—grey matter; (B) Astrogliosis—white matter; (C) Microglia activation—grey matter; (D) Microglia activation- white matter. Umbilical cord blood-derived cell therapy significantly decreased astrogliosis in both grey matter (p = 0.01) and white matter (p = 0.006), and decreased microglia activation in both grey matter (p < 0.0001) and white matter (p = 0.001).Abbreviations: admin, administration; ECFC, endothelial colony forming cells; EPC, endothelial progenitor cell; ICV, intracerebroventricular; IV, intravenous; MNC, mononuclear cell; PCB, preterm cord blood; TCB, term cord blood; Treg, T-regulatory cells; UCBC, umbilical cord blood cells.

Forest plot demonstrating the effect of umbilical cord blood-derived cell therapy on (A) Astrogliosis—grey matter; (B) Astrogliosis—white matter; (C) Microglia activation—grey matter; (D) Microglia activation- white matter. Umbilical cord blood-derived cell therapy significantly decreased astrogliosis in both grey matter (p = 0.01) and white matter (p = 0.006), and decreased microglia activation in both grey matter (p < 0.0001) and white matter (p = 0.001).Abbreviations: admin, administration; ECFC, endothelial colony forming cells; EPC, endothelial progenitor cell; ICV, intracerebroventricular; IV, intravenous; MNC, mononuclear cell; PCB, preterm cord blood; TCB, term cord blood; Treg, T-regulatory cells; UCBC, umbilical cord blood cells.