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The Ile2043Val missense variant in the SAMP3 domain of APC may impact the strength of interaction with AXIN. Human APC SAMP3 domain is shown in beige while the RGS domain of AXIN is coloured mauve. Isoleucine 2043 in wildtype human APC has four contacts with the AXIN RGS domain: three with Asp116 and one with Phe119. The valine substitution in APC is predicted to reduce the contacts with Asp116 to just one.
