Figure 3.

Alterations of lipid metabolism in GCK knockdown HepG2 cells. Lipid metabolites involved in fatty acid synthesis, glycerolipid metabolism, acylcarnitine metabolism, glycerophospholipid metabolism and sphingolipid metabolism were changed in hepatocytes after GCK knockdown. The Y-axis displays relative quantitative value of each lipid. Data are represented as mean ± SD. (n = 3) **** p ≤ 0.0001, ** p ≤ 0.01, * p ≤ 0.05 versus control group via Student’s t-test. The lipid metabolites in red represent upregulation, and those in green indicate downregulation. Acar, Acylcarnitine; Cer, Ceramides; DAG, Diacylglycerol; FA, Free fatty acid; GM3, Ganglioside; PC, Phosphatidylcholine; PE, Phosphatidylethanolamine; TAG, triacylglycerol.