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. 2023 Feb 25;24(5):4556. doi: 10.3390/ijms24054556

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© 2023 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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The DNA methylation/hydroxymethylation status of resolved vs. never-lesional epidermal keratinocytes. The DNA was hypo-methylated and hypo-hydroxymethylated in resolved vs. never-lesional epidermal keratinocytes. Hypo-methylated DNA is generally associated with open chromatin and transcription activation. Hence, the transcription might be more active in hypo-methylated DNA of resolved epidermal keratinocytes than never-lesional ones. Furthermore, hypo-methylated DNA in the resolved epidermis can reduce 5-hmC DNA levels. At the same time, the lower mRNA expression of TET3 enzyme might also be another reason for the loss of 5-hmC in the resolved epidermis. Abbreviations: 5-mC, 5-methylcytosine; 5-hmC, 5-hydroxymethylcytosine; TET3, ten-eleven translocation (TET)3.