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. 2023 Feb 25;24(5):4543. doi: 10.3390/ijms24054543

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© 2023 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Gene expression (left) and protein abundance (right) of CYPs in hepatitis C (HCV, n = 58) liver tissues stratified according to the Child–Pugh score into stages: A (n = 30), B (n = 21), and C (n = 7), and the controls (CTRL, n = 20). The data are represented as box-plots of the median (horizontal line), 75th (top of box) and 25th (bottom of box) quartiles, the smallest and largest values (whiskers) and mean (+). mRNA levels of the analyzed genes are expressed as relative amounts to the mean of five housekeeping genes (GAPDH, HMBS, PPIA, RPLP0, RPS9). Statistically significant differences: * p < 0.05, ** p < 0.01, *** p < 0.001 (Wilcoxon-signed rank test in comparison to the controls). (a) Results for CYP1A1, 1A2, 2B6, 2C8, 2C9 and 2C19. (b) Results for CYP2D6, 2E1 and 3A4.

Gene expression (left) and protein abundance (right) of CYPs in hepatitis C (HCV, n = 58) liver tissues stratified according to the Child–Pugh score into stages: A (n = 30), B (n = 21), and C (n = 7), and the controls (CTRL, n = 20). The data are represented as box-plots of the median (horizontal line), 75th (top of box) and 25th (bottom of box) quartiles, the smallest and largest values (whiskers) and mean (+). mRNA levels of the analyzed genes are expressed as relative amounts to the mean of five housekeeping genes (GAPDH, HMBS, PPIA, RPLP0, RPS9). Statistically significant differences: * p < 0.05, ** p < 0.01, *** p < 0.001 (Wilcoxon-signed rank test in comparison to the controls). (a) Results for CYP1A1, 1A2, 2B6, 2C8, 2C9 and 2C19. (b) Results for CYP2D6, 2E1 and 3A4.