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. 2023 Mar 6;24(5):5014. doi: 10.3390/ijms24055014

Figure 2.

Figure 2

Chemical structure of ganetespib. Ganetespib, 5-[2,4-dihydroxy-5-(1 methylethyl)phenyl]-2,4 dihydro-4-(1-methyl-1H indol-5 yl)-3H-1,2,4 triazole-3-one, is a powerful, small-molecule inhibitor of HSP90 that attaches to the ATP pocket in the N-terminus of HSP90, thus leading to a decrease in the levels of HSP90 customer proteins. It has a distinct triazolone-containing chemical structure and is distinct from other HSP90 inhibitors in terms of its potency, anti-tumor action, and safety [59].