Table 1.

Selection coefficients in the European population estimated by domain-adaptive SIA compared to previous estimates

		Estimates of selection coefficient
Gene	SNP	Domain-adaptive SIA	SIA* [12]	Previous estimates
KITLG	rs12821256	0.0035	0.0019	0.0161 [47]
ASIP	rs619865	0.0057	0.0019	0.0974 [47]
TYR	rs1393350	0.0028	0.0011	0.0112 [47]
OCA2	rs12913832	0.0093	0.0056	0.002 [47]; 0.036 [62]
MC1R	rs1805007	0.0027	0.0037	No selection [63]
ABCC11	rs17822931	0.0020	0.00035	~ 0.01 in East Asian [64]
LCT	rs4988235	0.0097	0.010	~ 0.01 [37,49,50]
TYRP1	rs13289810	Pneu > 0.5	Pneu > 0.5	No selection [47]
TTC3	rs1003719	Pneu > 0.5	Pneu > 0.5	No selection [47]
TCF7L2	rs7903146	Pneu > 0.5	Pneu > 0.5	N/A
ANKK1	rs1800497	Pneu > 0.5	Pneu > 0.5	N/A
FTO	rs9939609	Pneu > 0.5	Pneu > 0.5	N/A

^*The original SIA model in [12] uses genealogies inferred from simulations for training, despite the availability of ground truth genealogies.