Table 2.

Voxel-wise menopause stage effects on brain ¹⁸F-FES estrogen receptor density

Cluster extent	Coordinates x,y,z	Z	PFWE*	P voxel	Anatomical Region	Brodmann Area
Post-menopause > Peri-menopause > Pre-menopause
450	−31 11 36	4.39	0.007	< 0.001	Left Cerebrum, Frontal Lobe, Middle Frontal Gyrus	8
	−38 20 41	4.01		< 0.001	Left Cerebrum, Frontal Lobe, Middle Frontal Gyrus	8
259	17 44 25	4.37	0.021	< 0.001	Right Cerebrum, Frontal Lobe, Medial Frontal Gyrus	9
	15 35 32	3.20		< 0.001	Right Cerebrum, Frontal Lobe, Medial Frontal Gyrus	9
197	−50 −8 28	4.25	0.032	< 0.001	Left Cerebrum, Frontal Lobe, Precentral Gyrus	6
189	−29 −6 −8	3.87	0.034	< 0.001	Left Cerebrum, Sub-lobar, Lentiform Nucleus, Putamen
1071	−6 42 – 21	3.83	< 0.001	< 0.001	Left Cerebrum, Frontal Lobe, Orbital Gyrus	11
	−6 16 – 11	3.79		< 0.001	Left Cerebrum, Limbic Lobe, Anterior Cingulate	25
	−6 20 – 17	3.67		< 0.001	Left Cerebrum, Frontal Lobe, Medial Frontal Gyrus	25
205	−38 27 25	3.70	0.030	< 0.001	Left Cerebrum, Frontal Lobe, Middle Frontal Gyrus	9
Post-menopause > Pre-menopause
327	17 44 25	4.52	0.014	< 0.001	Right Cerebrum, Frontal Lobe, Medial Frontal Gyrus	9
	17 36 31	3.38		< 0.001	Right Cerebrum, Frontal Lobe, Medial Frontal Gyrus	9
522	−31 11 36	4.47	0.005	< 0.001	Left Cerebrum, Frontal Lobe, Middle Frontal Gyrus	8
	−38 20 41	4.09		< 0.001	Left Cerebrum, Frontal Lobe, Middle Frontal Gyrus	8
242	−50 −6 28	4.35	0.024	< 0.001	Left Cerebrum, Frontal Lobe, Precentral Gyrus	6
1126	−6 18 – 12	3.85	< 0.001	< 0.001	Left Cerebrum, Frontal Lobe, Anterior Cingulate gyrus	25
	−6 42 – 21	3.79		< 0.001	Left Cerebrum, Frontal Lobe, Orbital Gyrus	11
	−12 53 – 3	3.61		< 0.001	Left Cerebrum, Frontal Lobe, Superior Frontal Gyrus	10
242	−38 27 25	3.76	0.024	< 0.001	Left Cerebrum, Frontal Lobe, Middle Frontal Gyrus	9
Post-menopause > Peri-menopause
228	46 33 15	3.91	0.005	< 0.001	Right Cerebrum, Frontal Lobe, Middle Frontal Gyrus	46
88	−34 12 41	3.65	0.014	< 0.001	Left Cerebrum, Frontal Lobe, Middle Frontal Gyrus	6
	−28 12 35	3.33		< 0.001	Left Cerebrum, Frontal Lobe, Middle Frontal Gyrus	8
51	−28 48 – 6	3.59	0.020	< 0.001	Left Cerebrum, Frontal Lobe, Middle Frontal Gyrus	10
45	17 44 25	3.57	0.022	< 0.001	Right Cerebrum, Frontal Lobe, Medial Frontal Gyrus	9
50	32 48 – 4	3.56	0.020	< 0.001	Right Cerebrum, Frontal Lobe, Middle Frontal Gyrus	10
36	−52 −6 29	3.56	0.024	< 0.001	Left Cerebrum, Frontal Lobe, Precentral Gyrus	6
29	−41 46 – 10	3.43	0.026	< 0.001	Left Cerebrum, Frontal Lobe, Middle Frontal Gyrus	11
228	46 33 15	3.91	0.005	< 0.001	Right Cerebrum, Frontal Lobe, Middle Frontal Gyrus	46
88	−34 12 41	3.65	0.014	< 0.001	Left Cerebrum, Frontal Lobe, Middle Frontal Gyrus	6
	−28 12 35	3.33		< 0.001	Left Cerebrum, Frontal Lobe, Middle Frontal Gyrus	8
Peri-menopause > Pre-menopause
266	−28 −4 −8	4.10	0.011	< 0.001	Left Cerebrum, Sub-lobar, Lentiform Nucleus, Putamen
	−32 −7 −12	3.63		< 0.001	Left Cerebrum, Limbic Lobe, Amygdala
92	−49 –43 42	3.87	0.038	< 0.001	Left Cerebrum, Parietal Lobe, Inferior Parietal Lobule	40
82	−43 −15 49	3.80	0.042	< 0.001	Left Cerebrum, Frontal Lobe, Precentral Gyrus	4
74	12–62 21	3.69	0.045	< 0.001	Right Cerebrum, Occipital Lobe, Precuneus	31
65	−6 12–12	3.41	0.049	< 0.001	Left Cerebrum, Frontal Lobe, Anterior Cingulate Gyrus	25
110	−5 −41 32	3.37	0.033	< 0.001	Left Cerebrum, Limbic Lobe, Cingulate Gyrus	31

^*P<0.05 cluster-level corrected for multiple comparisons. Results are adjusted by age, plasma estradiol levels, and cerebellar uptake.