Skip to main content
. 2023 Feb 26;24(5):4585. doi: 10.3390/ijms24054585

Figure 7.

Figure 7

Effects of perinatal exposure to BPA on gene expression profile of GSH-related enzymes and oxidative damage in livers from female PND6 offspring. (A) Glutathione peroxidase (GPx); (B) glutathione reductase (GR); (C) glutathione S-transferase (GST); (D) γ-glutamylcysteine synthetase (γ-GCS) relative gene expression. (E) Malondialdehyde (MDA) content in nmol/mg protein. (F) Lipid hydroperoxide content in nmol/mg tissue. (G) Adenosine triphosphate (ATP) levels in nmol/mg protein. (H) Concentration of nitric oxide metabolites (NO) in nmol/μL plasma. (I) Concentration of 8-oxo-2′-deoxyguanosine (8-OHdG) in ng/mL. Data represent mean ± SD. For ELISA assay, n = 12 control PND6 offspring; n = 12 LBPA PND6 offspring; n = 12 HBPA PND6 offspring (two replicates for each sample). For mRNA, n = 12 control PND6 offspring; n = 12 LBPA PND6 offspring; n = 12 HBPA PND6 offspring (three replicates for each gene). Statistical significance was determined by one-way ANOVA. * p < 0.05; ** p < 0.01; *** p < 0.001.