Figure 6.

(a) Boxplots of lactate dehydrogenase A (Ldha) and lactate dehydrogenase B (Ldhb) in mild (green), moderate BLM (orange), moderate NINT (blue), and severe BLM (dark orange). Black dots represent the abundance of the selected features in all samples, yellow diamond represents the mean abundance. (b) Map of the pathways altered in moderate fibrosis and proteins modulated by nintedanib action (p-value_adj ≤ 0.05, FC ≥ 1.5 or ≤−1.5). The proteins upregulated and those downregulated in moderate fibrosis compared to mild are colored in red and green, respectively. BLM—bleomycin; NINT—nintedanib.