Table 1.
List of analyzed mice with their ID and treatment, average Ashcroft, Ashcroft frequencies, and fibrosis severity. Fibrosis severity was evaluated based on the average Ashcroft score: mild ( ≤ 3.5), moderate ( > 3.5 or ≤4.5), severe (> 4.5). * FFPE lung tissue blocks of these samples were prepared from both left and right lungs. SAL—saline; NINT—nintedanib; and BLM—bleomycin.
| Animal ID and Treatment | Average Ashcroft | Ashcroft Frequencies | Fibrosis Severity | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| 0 | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | |||
| 1856 (SAL) | 1.19 | 0 | 80.6 | 19.4 | 0 | 0 | 0 | 0 | 0 | 0 | Mild |
| 1857 (SAL) | 1.24 | 0 | 78 | 20 | 2 | 0 | 0 | 0 | 0 | 0 | Mild |
| 1860 (BLM 14d) | 5.03 | 0 | 0 | 2.8 | 8.6 | 20 | 34.3 | 20 | 14.3 | 0 | Severe |
| * 1862 (BLM 14d) | 4.95 | 0 | 0 | 0 | 4.9 | 31.7 | 31.7 | 26.8 | 4.9 | 0 | Severe |
| * 1864 (BLM 14d) | 5.94 | 0 | 0 | 0 | 0 | 12.1 | 18.2 | 33.3 | 36.4 | 0 | Severe |
| 1869 (BLM 21d) | 4.33 | 0 | 0 | 0 | 16.3 | 44.9 | 28.6 | 10.2 | 0 | 0 | Moderate |
| 1871 (BLM 21d) | 5.4 | 0 | 0 | 0 | 2.1 | 27.7 | 19.1 | 29.8 | 21.3 | 0 | Severe |
| 1873 (BLM 21d) | 3.94 | 0 | 0 | 0 | 34.3 | 48.6 | 5.7 | 11.4 | 0 | 0 | Moderate |
| 1874 (BLM 21d) | 3.98 | 0 | 0 | 0 | 34.6 | 42.3 | 15.4 | 5.8 | 1.9 | 0 | Moderate |
| 1875 (BLM 21d) | 3.92 | 0 | 0 | 0 | 41.7 | 36.1 | 11.1 | 11.1 | 0 | 0 | Moderate |
| 1891 (SAL) | 1.68 | 0 | 41.2 | 50 | 8.8 | 0 | 0 | 0 | 0 | 0 | Mild |
| 1892 (SAL) | 1.25 | 6.2 | 62.5 | 31.3 | 0 | 0 | 0 | 0 | 0 | 0 | Mild |
| 1893 (SAL) | 0.85 | 21.7 | 71.7 | 6.6 | 0 | 0 | 0 | 0 | 0 | 0 | Mild |
| 1938 (NINT 21d) | 3.77 | 0 | 0 | 0 | 40.9 | 43.2 | 13.6 | 2.3 | 0 | 0 | Moderate |
| * 1941 (NINT 21d) | 3.61 | 0 | 0 | 0 | 44.7 | 50 | 5.3 | 0 | 0 | 0 | Moderate |
| * 1943 (NINT 21d) | 4.66 | 0 | 0 | 3.1 | 12.5 | 21.9 | 46.9 | 9.4 | 6.2 | 0 | Severe |